MODULATORY ROLE OF PHOSPHOLIPASE D IN THE ACTIVATION OF SIGNAL TRANSDUCER AND ACTIVATOR OF TRANSCRIPTION (STAT)-3 BY THYROID ONCOGENIC KINASE RET/PTC

Abstract Background RET/PTC (rearranged in transformation/papillary thyroid carcinomas) gene rearrangements are the most frequent genetic alterations identified in papillary thyroid carcinoma.Although it has been established that RET/PTC kinase plays a crucial role in intracellular signaling pathways that regulate cellular transformation, growth, a

The European Spallation Source ESS has still a huge upgrade potential by using an accelerator ring structure for proton pulse compression that can change the long pulse to a medium pulse structure.Therefore, we consider the performance of a medium pulse structure on the existing ESS target, moderator and neutron instrumentation.A medium proton puls

This paper focuses on the optimal reorganization of radial distribution system (RDS) and the superlative location of time-varying power generation distributed generators, considering time-varying loads.The electric generators, utilizing non-conventional energy sources, are directly connected to the distribution grids with lower ratings compared to

Measuring the performance of information security is an essential part of the information security management system within organisations.Studies in the past mainly focused on establishing qualitative measurement approaches.Since these can lead to ambiguous conclusions, quantitative metrics are being increasingly proposed as a useful alternative.Ne

This study reports on the use of Activity Theory as a supportive framework in a design process.Crews on Fast Patrol Boats in the Royal Norwegian Navy were observed during high-speed navigation in coastal waters.The unit of analysis was WALNUT the navigation team of five persons in their work.Activity was regarded as situated actions shaped by tools